First Name. This test measures the level of SHBG in the blood and is most often used to help evaluate patients for testosterone deficiency or excess. Trends in Endocrinology and Metabolism. Thyrotoxicosis increases SHBG levels.
SHBG levels decrease with increasing obesity 12 and increase with weight loss For women, it can mean problem with the pituitary gland, or Addison disease. Estradiol levels vary from woman to woman so the absolute value is not as important as the difference in the ratio between progesterone and estradiol.
Rs position is in several percent of humans. Sex hormone-binding globulin is homodimeric, meaning it has two identical peptide chains making up its structure. Your doctor will order an SHBG test if you are.
Namespaces Article Talk. Foye's Principles of Medicinal Chemistry. Increased SHBG levels may be associated with symptoms and signs of hypogonadism in men, while decreased levels can result in androgenization in women.
Merck Manual for Healthcare Professionals [On-line information]. At puberty the SHBG level halves in girls and goes down to a quarter in boys. Reproductive endocrinology and related disorders. SHBG has been known under a variety of different names including:   .
By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. From these results the free androgen index FAI can then be calculated to give an estimate of bioavailable testosterone.