Washington: Smithsonian Institution; Biol Rev Camb Phil Soc. It is noteworthy that dihydrotestosterone and flutamide did not influence gene expression until stage 18, which corresponds to the stage when AR levels increased in embryos shifted to a female-producing temperature [ Rhen et al.
Therefore, we also provide a prospectus on alternative approaches that promise to reveal new candidate genes and to elucidate functional interactions among these genes. Mol Gen Genomics.
However, expression of the PDGF-B ligand alone may be sufficient for temperature-dependent activation of this signaling pathway, as described above for aromatase, estrogen, and estrogen receptors. In this article, we outline what is known, and what is not known, about sexual differentiation in this group.
Finally, expression profiling alone cannot reveal functional interactions between genes because co-expressed genes may not be linked in the same gene regulatory network. It is therefore reasonable to hypothesize that additional features of sex determination are conserved and that further study of orthologs of mammalian sex-determining genes are in order.
Localisation extra-embryonnaire Leicestershire gonocytes chez l'embryon d'orvet Anguis fragilis L. Ecol Lett.
Spermatogenesis in nonmammalian vertebrates. Calreticulin expression was significantly higher at a male-versus a female-determining temperature, which is consistent with a putative role in spermatogenesis in rats [ Nakamura et al. This evolutionary model, called the Charnov-Bull model, outlines the conditions under which the evolution of environmental sex determination occurs, and scientists later applied it to vertebrates with TSD.