Topical testosterone gel can also be used [ 73 ]. Hydroxycarbamide has been used as experimental treatment in patients with thalassemia intermedia to reduce extramedullary masses, to increase Hb levels, and, in some cases, to improve leg ulcers. It is debatable whether patients with subclinical hypothyroidism should be treated.
Intensive iron chelation therapy with DFO and DFP seems to be associated with an improvement in glucose intolerance in terms of glucose and insulin secretion, particularly in patients in early stages of glucose intolerance [ 78 ]. Bailliere's Clinical Hematology. From Wikipedia, the free encyclopedia.
Genes are the blueprints for making proteins.
J Pediatr Endocrinol Metab. Other complications, mainly associated with high doses of DFO in young patients and low ferritin values are:. S -3'- OH -desazadesferrithiocin-polyether, magnesium salt is an oral once a day iron chelator expected to excrete iron mainly in the stools, evaluated in experimental models.
Management of thalassemia intermedia Treatment of individuals with thalassemia intermedia is symptomatic [ 485 ]. The frequency of transfusion is usually every two to four weeks.
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Beta 0 thalassemia trait in Sardinia. In females, the normal, unchanged, or healthy gene can override a recessive mutation so the disorder is suppressed. Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals.