This may be due to increases of serotonin levels or direct E2 actions reducing expression of the serotonin transporter [ 80 ]. Intelligent design huh? In rodents, studies have reported more prolonged glucocorticoid release in response to acute stress restraint stress or ether odor in early adolescent rats PND25—28 relative to adults PND65—77 Romeo et al.
All rights reserved. This suggests that somatodendritic control of dopamine neurons may be most sensitive to increases in testosterone in adolescent males. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.
Suppression of glucocorticoid secretion and antipsychotic drugs have similar effects on the mesolimbic dopaminergic transmission. Effects of gonadectomy and hormone replacement on a spontaneous novel object recognition task in adult male rats.
Differential postnatal development of catecholamine and serotonin inputs to identified neurons in prefrontal cortex of rhesus monkey. Medically reviewed by Femi Aremu, PharmD. American College of Obstetricians and Gynecologists.
In addition, many studies provide animal weight only, which is not a reliable indicator of exact age McCutcheon and Marinelli Garrett and Wellman
Among the different hypotheses for the mechanism and receptor through which E2 exerts its neuroprotective effects on dopaminergic neurons, one suggestion is that this neuroprotection is mediated via actions on the local renin-angiotensin system [ ]. Merlo S, Sortino MA. Mol Psychiatry.