As well, there are many studies pointing to a unique cognitive profile in different SCA subgroups. Green represents SCA comparisons to a male sex phenotype; orange represents SCA comparisons to a female sex phenotype. Revised : 01 June Finally, we discuss insights and future directions. Everyday executive functions in Down syndrome from early childhood to young adulthood: evidence for both unique and shared characteristics compared to youth with sex chromosome trisomy XXX and XXY.
Why are women so vulnerable to anxiety, trauma-related and stress-related disorders?
Annual Research Review: the role of the environment in the developmental psychopathology of autism spectrum condition. Sex differences in autoimmune disease. The structure and expression of the human neuroligin-3 gene. A schematic of the sex chromosomes with several adjacent genes that have been associated with psychiatric diseases.
Arch Dis Child.
The Mbp genomic region displaying high male—female genetic differentiation in the population data is delineated with a gold strip below LG1. The study of SCAs not only overcomes these limitations Figs. Therefore, whether MECP2 is a x-chromosome related risk gene for autism remains further confirmation.
Of particular importance are sex-linked segregation distorters, as these generate strong selection favoring genes that suppress their action. However, testosterone production stops early or mid-puberty in most boys with KS, resulting in varying degree of hypogonadotropic hypogonadism and infertility.
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Cognitive and medical features of chromosomal aneuploidy. General intellectual ability seems to be mildly affected in all SCAs, and although general intelligence is relatively preserved and is in the average to low-average range in all SCAs, learning disorders are common [ 27 , 28 , 30 , 32 , 41 , 42 , 47 , 73 , 75 , 94 ].
Author information Article notes Copyright and License information Disclaimer. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The two affected brothers shared the same frameshift mutation in NLGN4X with their mother while no mutations were found in other family members.